Table 1.

Sepsis definitions.

Original sepsis definition (5)Systemic inflammatory process occurring in response to an infection
Original sepsis criteria (5)Two or more of the following in the setting of an infection:
Temperature <36 °C or >38 °C
Heart rate >90 beats/minute
Respiratory rate >20 breaths/minute or PaCO2 <32 mmHg (<4.3 kPa)
White blood cell count <4000 cells/mm3 or >12000 cells/mm3 or >10% immature neutrophils (bands)
Sepsis-3 definition (9)Life-threatening organ dysfunction caused by a dysregulated host response to infection
Sepsis-3 criteria (9)Increase in the SOFA score of at least 2 points from baseline in the setting of an infection