On the Cover This issue’s cover highlights a systematic review conducted by the CDC’s Laboratory Medicine Best Practice initiative on the impact of laboratory based clinical decision support tools. The tools assessed are intended to assist providers by alerting them of prescription orders that involve inappropriate medications or dosages at the time of ordering or dispensing. The tools examined also support patient management by identifying missing laboratory tests useful for monitoring medications, and test results that warrant consideration of therapeutic changes. Such evidence-based support tools will undoubtedly play a central role in future analytics that will be deployed in laboratory and clinical medicine. (See page 1035.) Reproduced with permission from istockphoto/mediaphotos & Ranta Images.